Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin
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چکیده
منابع مشابه
Response of peppermint to methyl jasmonate application .
Jasmonate compounds are known as new plant hormones that play important roles in the regulation of plant growth and development. Mints have been used and valued as aromatic herbs for thousands of years. Peppermint (Mentha piperita L.) is used for medicinal and food purposes and its essential oil is considered industrially important. Peppermint plants were grown in a greenhouse in pots. At flowe...
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Cisplatin is an anticancer drug that has enjoyed remarkable success against testicular tumors, but dose limiting side-effects have limited its application against a broader range of cancers. Previous studies have shown that high-mobility group (HMG) domain proteins such as HMG1 sensitize cells to cisplatin by shielding its major DNA adducts from nucleotide excision repair. Estrogen treatment in...
متن کاملGenes regulated by hepatocyte growth factor as targets to sensitize ovarian cancer cells to cisplatin.
Advanced ovarian cancers are initially responsive to chemotherapy with platinum drugs but develop drug resistance in most cases. We showed recently that hepatocyte growth factor (HGF) enhances death of human ovarian cancer cell lines treated with cisplatin (CDDP) and that this effect is mediated by the p38 mitogen-activated protein kinase. In this work, we integrated genome-wide expression prof...
متن کاملPerillyl alcohol: applications in oncology.
Perillyl alcohol is a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants. In animal studies it has been shown to regress pancreatic, mammary, and liver tumors, to exhibit possible application as a chemopreventative agent for colon, skin, and lung cancer, and as a chemotherapeutic agent for neuroblastoma, and prostate...
متن کاملThe therapeutic potential of hepatocyte growth factor to sensitize ovarian cancer cells to cisplatin and paclitaxel in vivo.
PURPOSE Advanced ovarian cancers are initially responsive to combinatorial chemotherapy with platinum drugs and taxanes but, in most cases, develop drug resistance. We recently showed that, in vitro, hepatocyte growth factor (HGF) enhances death of human ovarian cancer cell lines treated with cisplatin (CDDP) and paclitaxel. The present study addresses whether in vivo HGF makes ovarian carcinom...
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ژورنال
عنوان ژورنال: Anti-Cancer Drugs
سال: 2010
ISSN: 0959-4973
DOI: 10.1097/cad.0b013e32832a68ad